Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes
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چکیده
منابع مشابه
Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes
The effects produced in DNA by monofunctional or interstrand adducts of platinum(II) complexes have been summarized. The monofunctional adducts destabilize DNA in a sequence-dependent manner via conformational distortions, which may have a denaturational character. It has been suggested that this conformational alteration facilitates in DNA the formation of the bidentate DNA adducts, whose form...
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ژورنال
عنوان ژورنال: Metal-Based Drugs
سال: 1994
ISSN: 0793-0291
DOI: 10.1155/mbd.1994.195