Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes

The effects produced in DNA by monofunctional or interstrand adducts of platinum(II) complexes have been summarized. The monofunctional adducts destabilize DNA in a sequence-dependent manner via conformational distortions, which may have a denaturational character. It has been suggested that this conformational alteration facilitates in DNA the formation of the bidentate DNA adducts, whose form...

متن کامل

Monofunctional DNA-platinum(II) adducts block frequently DNA polymerases.

The question of whether monofunctional DNA platinum(II) adducts block synthesis of DNA by purified DNA polymerases of different types and origin has been investigated by comparing the time dependence of synthesis arrest and of DNA adduct formation. Activated salmon testis DNA is used as a suitable substrate for DNA synthesis allowing to probe inhibition by platinum(II) monoadducts for the varie...

متن کامل

Formation of monofunctional cisplatin-DNA adducts in carbonate buffer.

Carbonate in its various forms is an important component in blood and the cytosol. Since, under conditions that simulate therapy, carbonate reacts with cisplatin to form carbonato complexes, one of which is taken up and/or modified by the cell [C.R. Centerwall, J. Goodisman, D.J. Kerwood, J. Am. Chem. Soc., 127 (2005) 12768-12769], cisplatin-carbonato complexes may be important in the mechanism...

متن کامل

Stability of adriamycin-induced DNA adducts and interstrand crosslinks

The stability of adriamycin-induced DNA adducts and interstrand crosslinks was measured at 37 degrees C by three independent procedures. The loss of [14C]-labelled adducts was described by two first-order decays with half-lives of 7.4 h (60% amplitude) and 39 h (40%). The loss of the drug chromophore also exhibited a biphasic character, with half-lives of 6 h (65%) and approximately 150 h (35%)...

متن کامل

DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses.

It is a testimony to the complexity of cancer that cytotoxic drugs are still a mainstay of therapeutic approaches to treat that disease. Perhaps even more paradoxical is the fact that cytotoxic therapy has its origin in the highly toxic mustard gas, which was developed for chemical warfare in the First World War. As with other crosslinking agents, such as mitomycin C, the chloroethylnitroso ure...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Metal-Based Drugs

سال: 1994

ISSN: 0793-0291

DOI: 10.1155/mbd.1994.195